In the brains of people that suffer from long-term multiple sclerosis (MS), inflammatory cells are not entering the brain via the bloodstream anymore. Instead, the cells arise from local memory cells in the brain. Nina Fransen and her colleagues of…
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Blood cells could serve as a ‘thermometer’ to detect breast cancer
Immune system cells in the blood of breast cancer patients undergo alterations early in the disease course, according to a study published in the journal Clinical & Translational Immunology. The authors believe that this discovery may contribute to the early…
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Coronavirus SARS-CoV-2 infects cells of the intestine
Researchers from the Hubrecht Institute in Utrecht, Erasmus MC University Medical Center Rotterdam, and Maastricht University in the Netherlands have found that the coronavirus SARS-CoV-2, which causes COVID-19, can infect cells of the intestine and multiply there. Using state-of-the-art cell…
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A new strategy to trigger ferroptosis in target cancer cells using drug-metal coordination complexes
Rapidly increasing cancer incidence and mortality worldwide have raised great challenges for the currently available anticancer options, which warrants the development of new therapeutic modalities based on novel antitumor mechanisms. Ferroptosis, a recently discovered form of non-apoptotic cell death, is…
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Researchers restore sight in mice by turning skin cells into light-sensing eye cells
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes. The work, funded by the…
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Researchers developing antibodies ‘neutralize’ novel coronavirus before it invades cells
University of Toronto researcher Sachdev Sidhu and his collaborators are engineering antibody molecules that can neutralize the novel coronavirus in the body before it invades cells. The investigator at the Donnelly Centre for Molecular and Biomolecular Research is part of…
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Discovery that cells inject each other opens new line of attack on cancer
Although most cancer cells are killed by chemotherapy, individual cells vary in their sensitivity, so that some cancer cells often escape. Diversity among cancer cells is thus an issue for cancer treatment. Previously diversity was thought to be mostly due…
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Old human cells rejuvenated with stem cell technology, research finds
Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine. The…
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Engineered bone marrow cells slow growth of prostate and pancreatic cancer cells
In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel…
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Gene responsible for controlling activity of T follicular cells identified
A team of researchers at the University of Texas Southwestern Medical Center has identified the gene responsible for controlling the activity of T follicular helper (TFH) cells. In their paper published in the journal Science Immunology, the group describes their…
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