In Norway, all newborn children are tested for 25 rare genetic diseases through the Newborn Screening program, and the most common of these is phenylketonuria (abbreviated to PKU), known as Folling Disease. Every year, between 3-7 children are born in…
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FDA-approved antidiarrhea drug can reverse resistance to chemotherapy in a mouse model of leukemia
New research into one of the most common and difficult cancers to treat has revealed an effective route to mitigating chemotherapy resistance through the use of a drug already approved by the FDA to treat diarrhea. The findings are published…
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Model identifies risk of serious complications following surgery
Heart attack, kidney failure, stroke. These are just a few of the life-threatening complications that patients are at risk for following surgery. Now Jefferson researchers have developed an easy-to-use, web-based tool that predicts the risk of post-surgical complications such as…
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He Wanted to Be a Healthier Role Model for His Kids, So He Ran Off 190 Pounds
Name: Daniel HertelAge: 28Hometown: Buffalo Start Weight: 378 poundsEnd Weight: 188 poundsTime Running: 10 months Before I went on my weight-loss journey, I weighed nearly 400 pounds. Because of this, I was always out of breath and tired—not to mention…
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Study identifies a nonhuman primate model that mimics severe COVID-19 similar to humans
Aged, wild-caught African green monkeys exposed to the SARS-CoV-2 virus developed acute respiratory distress syndrome (ARDS) with clinical symptoms similar to those observed in the most serious human cases of COVID-19, report researchers in The American Journal of Pathology, published…
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Researchers create an animal model for studying GPI anchor deficiencies
Impaired intelligence, movement disorders and developmental delays are typical for a group of rare diseases that belong to GPI anchor deficiencies. Researchers from the University of Bonn and the Max Planck Institute for Molecular Genetics used genetic engineering methods to…
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COVID-19 unmasked: Math model suggests optimal treatment strategies
Getting control of COVID-19 will take more than widespread vaccination; it will also require better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as…
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Getting it just right: The Goldilocks model of cancer
Sometimes, too much of a good thing can turn out to be bad. This is certainly the case for the excessive cell growth found in cancer. But when cancers try to grow too fast, this excessive speed can cause a…
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COVID-19 model inspired by gas-phase chemistry predicts disease spread
A COVID-19 transmission model inspired by gas-phase chemistry is helping the Centers for Disease Control and Prevention (CDC) forecast COVID-19 deaths across the country. Developed by Yunfeng Shi, an associate professor of materials science and engineering at Rensselaer Polytechnic Institute,…
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Researchers test a comprehensive model intervention to reduce opioid overdose deaths in hard-hit communities
National Institutes of Health and other federal leaders outlined their vision for a groundbreaking study that will aim to address gaps in reaching communities most heavily affected by the opioid epidemic with proven, evidence-based interventions for opioid use disorder (OUD)….
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