Exercise intensity appears to make no difference to risk of mortality among older adults, suggests a randomised controlled trial from Norway published by The BMJ today. Physical activity has been highlighted as one of the most important actions people of…
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Explaining vaccine clinical trial phases
Clinical trials are conducted in phases, each with slightly different objectives and increasing numbers of volunteers. This is primarily to ensure subject safety but also to make sure the process is as cost-effective as possible. The data from each phase…
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First randomised trial backs safety of common heart drugs in COVID-19 patients
Heart patients hospitalized with COVID-19 can safely continue taking angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), according to the BRACE CORONA trial presented in a Hot Line session today at ESC Congress 2020. ACE inhibitors and ARBs are…
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German-Chinese coronavirus vaccine trial begins in China
Clinical trials on humans have begun in China for a potential coronavirus vaccine developed by German pharmaceutical group BioNTech with Chinese company Fosun Pharma, the companies said Wednesday. Seventy-two participants have already received their first dose following approval for the…
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NIH trial to test antibodies and other therapeutics for mild, moderate COVID-19
A Phase 2 clinical trial will evaluate the safety and efficacy of potential new therapeutics for COVID-19, including an investigational therapeutic based on synthetic monoclonal antibodies (mAbs) to treat the disease. Researchers sponsored by the National Institute of Allergy and…
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‘No benefit’ from hydroxychloroquine for virus: UK trial
A major British trial of hydroxychloroquine has found it has “no benefit” for patients hospitalised with the coronavirus, researchers said Friday, announcing they had stopped tests of the drug. “We have concluded that there is no beneficial effect of hydroxychloroquine…
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense…
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Closely watched arthritis drug disappoints in COVID-19 trial
An arthritis drug that was being closely watched for its potential use against COVID-19 has delivered disappointing results in clinical trials, its makers said Monday. Kevzara, which is made by Regeneron and Sanofi, does not attack the novel coronavirus but…
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Clinical trial launches to evaluate antimalarial drugs for COVID-19 treatment
Washington University School of Medicine in St. Louis is launching a clinical trial for patients hospitalized with COVID-19 at Barnes-Jewish Hospital. The trial will investigate the effectiveness of different combinations of the antimalarial drugs chloroquine and hydroxychloroquine and the antibiotic…
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Japan’s Fujifilm starts Avigan trial to treat coronavirus
Japan’s Fujifilm has begun clinical trials to test the effectiveness of its anti-flu drug Avigan in treating patients with the new coronavirus, after reports of promising results in China. Trials in China have suggested Avigan could play a role in…
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