The blockage of lung arteries by a blood clot results in pulmonary embolism—a condition requiring emergency care that affects more than 300,000 people in the United States each year. Existing treatments, however, may not fully remove the clot, necessitating the…
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A novel method to block HIV in mice
Researchers at City of Hope, a world-renowned research and treatment organization for cancer and diabetes, and Menzies Health Institute Queensland at Griffith University have developed a novel anti-HIV protein that suppressed HIV levels in the bone marrow, spleen and brain…
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Study: 15 novel biomarkers for diseases predisposing to dementia discovered
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins…
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A novel neurological disorder associated with the Polycomb complex identified
A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder. This Undiagnosed Diseases Network (UDN) study was led by Dr. Shinya Yamamoto, investigator at the Jan and Dan Duncan Neurological…
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Novel interactions between proteins that help in recovering from brain injury
Patients with brain injury (caused by stroke or trauma) primarily rely on rehabilitation therapy for recovery, as there are no other known effective treatment methods. The rate of recovery from brain injury observed in adults is significantly slower (or the…
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Novel radiopharmaceutical tracks ‘master switch’ protein responsible for cancer growth
A protein that is critical in cancer cell metabolism has been imaged for the first time with a newly developed radiopharmaceutical, 18F-DASA-23. Imaging with this novel agent has the potential to improve the assessment of treatment response for patients, specifically…
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A novel tuberculosis regimen shortens treatment course for patients
Tuberculosis (TB) is a deadly infection that occurs in every part of the world. The standard treatment for TB, a six-month multidrug regimen, has not changed in more than 40 years. Patients can find it difficult to complete the lengthy…
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Novel sensor discovered that helps bacteria detect and respond to formaldehyde
Bacteria called methylotrophs can use methane and methanol as fuel; in doing so, they produce large amounts of formaldehyde during growth, but until recently no one knew how they detected and responded to this toxic compound. Publishing on 26th May,…
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Novel immune checkpoints have applications for cancer, autoimmune disease treatment
The immune system is a complex balancing act; if it overreacts or underreacts to foreign molecules, there can be serious health consequences. For cancer patients, tumor progression is often accompanied by immunosuppression, meaning their bodies can’t fight off pathogens the…
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Japanese-European research team discovers novel genetic mitochondrial disorder
DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA. The human genome encodes three different DNA ligase proteins, but only one of them—DNA ligase III…
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