Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical…
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Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy
Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It covers 10-15% of all breast cancer cases, has a high risk of late recurrence, unique metastatic sites, high sensitivity…
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Novel hybrid device to boost research on metastatic process of breast cancer cells
European researchers are working on a novel hybrid device to better understand the metastatic process of cancer cells traveling from breast to bone and fast screen new drugs against it. The spread of cancer cells to other parts of the…
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Study reveals new strategy for reducing tumor growth, metastasis
A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma. The findings, reported in the journal Cancer Immunology Research, add mechanistic…
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Cancer: Tumor driver promoting EMT, metastasis and resistance to therapy
Cancer metastasis, which is the dissemination of tumor cells into distant organs, is the leading cause of mortality in cancer patients. To undergo metastasis, cells must leave the primary tumor, circulate into the blood, colonize distant organs, and form distant…
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Small molecule treatment reduces colon cancer metastasis
When cancer metastasizes and spreads throughout the body, it can severely change the prognosis of the disease. It is estimated that metastasis is responsible for 90 percent of cancer deaths. University of Chicago Medicine investigators have found a new way…
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Team creates a collaborative platform to streamline brain metastasis research
Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result,…
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