Researchers in the United States have developed an alternative messenger RNA (mRNA) delivery platform to the lipid nanoparticles that are currently used in vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019…
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Experimental evidence that ADAM17 inhibition prevents severe COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that is contagious in humans. It is the causal agent of the ongoing coronavirus 2019 (COVID-19) pandemic. This virus causes a mild to severe infection and has…
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Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape
The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered an intensive hunt for effective new and repurposed antivirals and antibodies, for prevention and treatment of the infection. A new preprint…
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Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants
A new monoclonal antibody targets a particular region of the receptor-binding domain (RBD) on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This region is usually not accessible to immune cells, which may be why it has broad neutralizing capabilities….
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Identification of specific anti-SARS-CoV-2 antibodies with cross-neutralization potency
A team of scientists from the USA and Canada recently characterized the cross-neutralizing potency of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies isolated from coronavirus disease 2019 (COVID-19) patients. The findings reveal that some of the isolated antibodies targeting…
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Neutralizing antibodies to SARS-CoV-2 in mice depend on Fc effector function
The onset of the coronavirus disease 2019 (COVID-19) brought about intensive research on the biological characteristics of the pathogen responsible, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immune response mediated by neutralizing antibodies, elicited by the virus or…
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Novel host-viral-microbiome interactions during COVID-19 may determine outcome
The current pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading rapidly for over a year. Though primarily a respiratory illness, its manifestations are often protean and may be life-threatening….
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Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers
Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further…
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Polyphenols may provide protective effect against COVID-19 disease
According to the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU), as of today, February 22nd, 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 111 million individuals worldwide. COVID-19 disease, caused by…
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New research aims to explore functions of bile acids in the gut stem cell niche
Examining gut health from a different angle, Flinders University’s Associate Professor Robyn Meech is looking at what can trigger colon cancer – and she believes bile acids may provide a significant piece of the puzzle. Image Credit: Flinders University Associate…
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