If not caught quickly, cancer cells often spread to other organs in a process called metastasis. Lymph nodes (LNs) are the organs with the highest risk of metastasis. Metastasis in the LNs also influences cancer staging and treatment planning, and…
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More memory B cells exist in those fully vaccinated with previous SARS-CoV-2 infection, study says
A new study by University of Minnesota Medical School researchers is revealing that some people who received an mRNA vaccination for COVID-19 have greater immune responses compared to others. While the vaccine induces strong immune responses against the virus in…
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New findings on B cells may improve vaccine design
Our bodies can fine-tune the immune response to an infection and make it proportional to the threat at hand. New research from Karolinska Institutet in Sweden describes how B lymphocytes, the immune cells that make antibodies, choose between different cell…
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Heat-controllable CAR T cells destroy tumors and prevent relapse in new study
A team of researchers led by bioengineers at the Georgia Institute of Technology is expanding the precision and ability of a revolutionary immunotherapy that is already transforming oncology. CAR T-Cell therapy has been hailed by patients, clinical-researchers, investors, and the…
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Skin cells from frontotemporal dementia patients may reveal disease mechanisms and biomarkers for drug research
A new study from the University of Eastern Finland suggests that skin fibroblasts from frontotemporal dementia patients may be useful in investigating underlying disease mechanisms as well as in biomarker and drug research. Frontotemporal dementia (FTD) is the second most…
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A closer look at the cells combating a deadly lung disease
Single-cell RNA sequencing has revealed a subset of cells that could provide protection from a rare, but severely debilitating and fatal, lung disease. The findings were published by Nagoya University researchers and colleagues in the European Respiratory Journal. Further research…
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How ‘paralyzed’ immune cells can be reactivated against brain tumors
Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body’s immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim and Freiburg discovered this mechanism, and at the…
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Brain cells decide on their own when to release pleasure hormone
In addition to smoothing out wrinkles, researchers have found that the drug Botox can reveal the inner workings of the brain. A new study used it to show that feedback from individual nerve cells controls the release of dopamine, a…
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New mechanism by which senescent cells turn on genes encoding for tumor-regulating factors
Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment. The study, published in Nature Cell Biology, reports that…
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Aging cells in abdominal fluid cause increased peritoneal dissemination of gastric cancer
Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that cellular senescence of cancer-associated fibroblasts (CAFs) play an important…
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