Alzheimer’s disease (AD) is one of the three so-called trillion-dollar diseases in the world, next to cancer and diabetes. It is expected that in the next 40 years, the number of people diagnosed with AD will triple. Today, there is…
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Researchers investigate inhibitory mechanism in Alzheimer’s disease
Alzheimer’s disease (AD) is a form of progressive dementia interfering with daily living. It is caused by the decline in the number of brain cells resulting in the deterioration of our mental abilities. One of the main reasons for the…
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In surprising twist, some Alzheimer’s plaques may be protective, not destructive
One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they’ve largely failed in clinical trials. New research by Salk scientists upends…
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Imbalance in gum bacteria linked to Alzheimer’s disease biomarker
Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta—a key biomarker for Alzheimer’s disease—in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill…
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New research on Alzheimer’s disease shows ‘lifestyle origin at least in some degree’
For years, research to pin down the underlying cause of Alzheimer’s disease has been focused on plaque found to be building up in the brain in AD patients. But treatments targeted at breaking down that buildup have been ineffective in…
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Experimental antibodies for Parkinson’s, Alzheimer’s may cause harmful inflammation
A team led by scientists at Scripps Research has made a discovery suggesting that experimental antibody therapies for Parkinson’s and Alzheimer’s have an unintended adverse effect—brain inflammation—that may have to be countered if these treatments are to work as intended….
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Nanoparticles help untangle Alzheimer’s disease amyloid beta plaques
Scientists are still a long way from being able to treat Alzheimer’s Disease, in part because the protein aggregates that can become brain plaques, a hallmark of the disease, are hard to study. The plaques are caused by the amyloid…
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Genetic study of Lewy body dementia supports ties to Alzheimer’s and Parkinson’s diseases
In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with…
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Researchers explore link between ‘Alzheimer’s gene’ and COVID-19
A City of Hope-led research team found that the same gene that increases the risk for Alzheimer’s disease, ApoE4, can increase the susceptibility to and severity of COVID-19. “Our study provides a causal link between the Alzheimer’s disease risk factor…
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First observation of the early association between proteins linked to Alzheimer’s disease
During the pre-clinical stages of Alzheimer’s disease, i.e. when subtle changes are taking place in the brain but no cognitive symptoms can be observed, the cortex presents a state of transient hyperexcitability. To date, several studies conducted in animals have…
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