Major study shows prostate cancer treatment has significant impact on quality of life

Major study shows prostate cancer treatment has significant impact on quality of life

Findings from the first international prostate cancer quality of life study conducted by patients themselves reports that significant numbers of men treated for the disease are struggling with continence and sexual problems after treatment. Results suggest that any treatment apart from active surveillance may negatively affect quality of life, and indicate that for many men these effects may be greater than previously thought.

The findings of the Europa Uomo Patient Reported Outcomes Study (EUPROMS) were announced today by Europa Uomo Chairman André Deschamps at the European Association of Urology’s Virtual Congress. He reported that “The analysis of survey responses showed that urinary incontinence and sexual function were the two areas where men reported the lowest quality of life scores—much lower compared to the averages reported in clinical studies”.

EUPROMS gathered data from 2,943 European men from 25 countries. The respondents had an average age of 70 (all were over 45), and on average had been diagnosed with prostate cancer at the age of 64, meaning that they were reporting on quality of life 6 years after treatment.

Overall, 50% of men who replied to the questionnaire and had been treated for prostate cancer said that loss of sexual function (including the ability to have an erection or reach orgasm) was a big (28%) or moderate (22%) problem for them.

“We often hear that decline in sexual functioning is a relatively small problem for prostate cancer patients and the effect on their quality of life should not be exaggerated,” said André Deschamps. “We also hear that prostate cancer is typically a disease of ‘old men’, implying that the loss of sexual function is less relevant. This survey paints a different picture.”

Respondents also report that different treatments have different effects on quality of life; radical prostatectomy (surgical removal of the prostate) has the largest reported impact on urinary incontinence. Radiotherapy was shown to double the fatigue a patient experiences in comparison to surgery, whereas chemotherapy triples the fatigue score. The impact of radiotherapy on sexual function is worse than radical prostatectomy but both have a severe impact.

Results indicate that the best quality of life scores are seen where the cancer is discovered in an early, curable stage. “This means efforts toward early detection and awareness are essential to avoid unnecessary deterioration in quality of life. Wherever it is possible and safe, active surveillance should be considered the first line treatment to ensure best quality of life.” said André Deschamps.

He continued, “Our findings provide patients and health care professionals with a snapshot of the impact of treatments. We hope they will be used to set realistic expectations of the effects of the different treatments for prostate cancer on quality of life. They show that the effects of prostate cancer often don’t stop after treatment, and even those who are treated successfully for their cancer may have significant problems”.

He added “The results of this survey are different from clinical studies using the same validated questionnaires. This doesn’t replace previous studies, but it does, suggest further investigation is needed. This is a huge survey, which is the great strength of the work, so I’d like to say thank you to all patients and volunteers who spent hours making this survey a success.”

Commenting, Professor Arnulf Stenzl (Tübingen University, Germany), the European Association of Urology’s Adjunct Secretary General—Executive Member Science, said:

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