A team of researchers working at the Indiana University School of Medicine, has developed a compound that can degrade the cancer-promoting protein SUMO1. In their paper published in the journal Science Translational Medicine, the group describes their work in attempting…
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Drug-like molecule points to novel strategies for cancer therapy
A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. In a new study in Cell Chemical Biology,…
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Natural substance protects nerve cells from the damage caused by neurodegenerative diseases
University of Tübingen research team investigates bacteria-made agent which may counter the damage of Alzheimer´s disease. An international research team led by Professor Stephanie Grond from the Institute of Organic Chemistry at the University of Tübingen has found that the…
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New chemical process uses photocatalytic membrane to remove steroid hormones
Micropollutants such as steroid hormones contaminate drinking water worldwide and pose a significant threat to human health and the environment even in smallest quantities. Until now, easily scalable water treatment technologies that remove them efficiently and sustainably have been lacking….
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HP1a is a key epigenetic regulator that maintains chromosome integrity
The information of the human genome is encoded by approximately 3 billion DNA base pairs and packaged into 23 pairs of chromosomes. If all chromosomes could be disentangled and linearly aligned, they would be a thin thread of about 2…
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New machine learning method for designing more effective antibody drugs
Antibodies are not only produced by our immune cells to fight viruses and other pathogens in the body. For a few decades now, medicine has also been using antibodies produced by biotechnology as drugs. This is because antibodies are extremely…
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Researchers explore an inhalable SARS-CoV-2 nanobody therapy
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the world’s third major coronavirus outbreak. To date, the SARS-CoV-2 has infected over 135 million lives and caused over 2.9 million deaths. Even…
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Discovering DNA methylation from bacteria and microbiome using nanopore technology
Journal name: Nature Methods Title of the article: Discovering multiple types of DNA methylation from individual bacteria and microbiome using nanopore sequencing Corresponding author: Gang Fang, PhD Bottom line: Bacterial DNA methylation occurs at diverse sequence contexts and plays important…
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Researchers unravel how a novel microbial small molecule is connected to dental caries development
An inter-disciplinary team of researchers led by Prof. Qian Peiyuan, Chair Professor at the Hong Kong University of Science and Technology (HKUST)'s Department of Ocean Science and Division of Life Science has unraveled how a novel microbial small molecule released…
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Glycan switch may explain why SARS-CoV-2 causes such variable symptoms
Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others. Salome Pinho from the…
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