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Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
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Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis

04/11/2021

Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical…

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