The bacteria living in the intestine consist of some 500 to 1000 different species. They make up what is known as the intestinal flora, which plays a key role in digestion and prevents infections. Unlike pathogens that invade from the…
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The comparative effectiveness of neutralizing monoclonal antibodies against SARS-CoV-2
During the coronavirus disease 2019 (COVID-19) pandemic, the FDA authorized the emergency use of neutralizing monoclonal antibodies (mAbs) to treat mild to moderate COVID-19 patients at risk of progression to a more severe prognosis. This was done in an attempt…
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Immunological differences in Moderna and Pfizer-BioNTech vaccine-induced Fc-functional profiles
The perseverance of scientists worldwide has led to the rapid development of many SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccines and provided preventative measures against the coronavirus 2019 (COVID-19) pandemic. However, there have been many cases of breakthrough infections,…
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Regional differences in prevalence of SARS-CoV-2 antibodies in children
In general, children are less frequently affected by the coronavirus disease 2019 (COVID-19) as compared to adults. The infection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for COVID-19, in children are not well…
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COVID-19 vaccine elicits antibody responses in nearly 9 out of 10 people taking immunosuppressants
COVID-19 vaccination elicited antibody responses in nearly nine out of 10 people with weakened immune systems, although their responses were only about one-third as strong as those mounted by healthy people, according to a study by researchers at Washington University…
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Next-gen COVID vaccine to make persistent neutralizing antibodies
Scientists and pharmaceutical companies have successfully generated vaccines to fight the coronavirus disease (COVID-19) pandemic. Most of these vaccines are very effective in combating the disease. However, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus that has…
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Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern
Large scale vaccination campaigns against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been implemented in several countries around the world. Although SARS-CoV-2 antibodies are not the only method that can be used to determine immunity against this virus,…
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Prior treatment may impact efficacy of ACT-TIL in patients with metastatic melanoma
Bottom Line: Patients with metastatic melanoma that had relapsed on anti-PD-1 therapies or BRAF/MEK inhibitors did not respond as well to an investigational therapy that involves the adoptive cell transfer of tumor-infiltrating lymphocytes (ACT-TIL) as patients naïve to these treatments….
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Study examines prevalence of neutralizing antibodies to HCoV-NL63 in healthy adults in Australia
Several coronaviruses are known to infect a wide range of hosts that includes many animals and humans. The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This coronavirus is an extremely infectious, positive-sense,…
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Pfizer CEO to public: Just trust us on the covid booster
Pfizer CEO Albert Bourla was confident in June about the ability of his company's vaccine to protect against the highly contagious delta variant, as it marched across the globe and filled U.S. hospitals with patients. "I feel quite comfortable that…
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