The US Food and Drug Administration has given marketing clearance to CognICA, an artificial intelligence–powered integrated cognitive assessment for the early detection of dementia. Developed by Cognetivity Neurosciences Ltd, CognICA is a 5-minute, computerized cognitive assessment that is completed using…

A higher polygenic risk (PGR) score may predict late-onset Alzheimer’s disease (LOAD), new research shows. Investigators found a higher PGR was significantly linked to smaller hippocampal volume and poorer executive function in physically and cognitively healthy adults. “Our study is…

There are important differences in the diagnostic accuracy of blood tests used to screen for Alzheimer’s disease (AD). Some mass spectrometry (MS)–based plasma tests can detect brain amyloid β (Aβ) pathology. Investigators compared the performance of eight plasma Aβ42/40 assays…

Hyperbaric oxygen therapy (HBOT) increases cerebral blood flow and improves cognitive performance in older adults with memory problems, early research suggests.   “By treating vascular dysfunction, we’re mapping out the path toward Alzheimer’s prevention,” study investigator Shai Efrati, MD, with…

Drinking six or more cups of coffee a day is associated with smaller brain volume and a 53% increased risk for dementia, results of a large study suggest. “With coffee intake, moderation is the key, and especially high levels of…

A review of human and animal epidemiological studies found that long-term stress and genetic factors may act through the hypothalamic-pituitary-adrenal (HPA) axis ¢a pathway in the brain that mediates stress responses ¢to contribute to the development of Alzheimer’s disease. The…