Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China at the end of 2019, several new variants have also been identified. As of July 29, 2021, the coronavirus disease 2019 (COVID-19), which is the…
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Engineered T cells prevent translational shutdown in SARS-CoV-2 infected cells
Once severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) successfully enters a host cell, the virus adopts host machinery to facilitate replication and proliferation, abrogating host messenger RNA (mRNA) translation in this process. The production of interferon and interferon-stimulated genes within…
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Neuropathology of COVID-19 patients caused by infection of brain pericytes
Coronavirus disease 2019 (COVID-19) primarily causes respiratory symptoms that range from mild cough and fever to severe pneumonia. Increasingly, studies indicate that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an organotropism beyond the respiratory tract and that the…
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Researchers identify aluminum hydroxide/TLR9 agonist as potential adjuvant to improve RBD-based COVID-19 vaccine efficacy
A team of scientists from the United States has recently developed a formulation of toll-like receptor 9 (TLR9) agonist and aluminum hydroxide to increase the immunogenicity of spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The…
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Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines
Researchers in the United States have developed an alternative messenger RNA (mRNA) delivery platform to the lipid nanoparticles that are currently used in vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019…
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Can biomaterials offer novel therapeutic strategies against COVID-19?
The global coronavirus disease 2019 (COVID-19) pandemic rages on. To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has infected over 138.3 million and caused over 2.9 million deaths the world over. Despite major gains…
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Experimental evidence that ADAM17 inhibition prevents severe COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that is contagious in humans. It is the causal agent of the ongoing coronavirus 2019 (COVID-19) pandemic. This virus causes a mild to severe infection and has…
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Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape
The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered an intensive hunt for effective new and repurposed antivirals and antibodies, for prevention and treatment of the infection. A new preprint…
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Researchers explore an inhalable SARS-CoV-2 nanobody therapy
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the world’s third major coronavirus outbreak. To date, the SARS-CoV-2 has infected over 135 million lives and caused over 2.9 million deaths. Even…
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Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants
A new monoclonal antibody targets a particular region of the receptor-binding domain (RBD) on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This region is usually not accessible to immune cells, which may be why it has broad neutralizing capabilities….
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