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Changes to primary endpoints in phase 3 cancer trials occur frequently and are often undisclosed in study manuscripts, new research shows. Among 755 randomized controlled cancer trials registered in ClinicalTrials.gov, 145 (19%) had their primary endpoints changed after the trial…

Major fungal infections have become more common across the globe, and one unexpected phenomenon among the rise of fungi is life-threatening infections as a result of a complication of certain immunotherapies and small molecule kinase inhibitors. A scientist at the…

In the United States, low-income immigrant and minority children often live in environments that have highly polluted air. A study led by researchers at the University of California, Riverside, and published in International Journal of Environmental Research and Public Health…

A team of design engineers and environmental hygienists from Imperial College London, the London School of Hygiene, Tropical Medicine and the University of Dar es Salaam has developed a dispensable soap tab system to increase handwashing in poor areas. In…

Electroconvulsive therapy (ECT) is the gold standard treatment for resistant depression, but results of a new randomized, head-to-head trial suggest intravenous ketamine is at least as effective and has fewer side effects. “The take-home message right now is that if…

While physicians are getting less of a Medicare pay cut than they thought this year (Congress voted to cut Medicare payments by 2%, which was less than the expected 8.5%), Medicare still pays physicians only 80% of what many third-party…

In this work, data from the UK Biobank were used to investigate the association of both individual and combined healthy lifestyle factors with the risk of all-cause and cause-specific mortality among 104,142 people with osteoarthritis. The researchers gave each person…

The prophylactic use of antiemetic, antipyretic, or antibiotic drugs in older patients with acute stroke did not reduce the risk of poor functional outcome in the PRECIOUS trial. “The results of PRECIOUS do not support preventive use of antiemetic, antipyretic,…

Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to…

In a recent editorial piece published in the Nutrients Journal, researchers from Spain discussed the impact of lifestyle and modifiable behaviors such as exercise and diet and their interactions on human health across ages. Study: Effects of Diet—Exercise Interaction on Human…