MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD. Because members of the pro-survival BCL2 family proteins are promising targets of pharmacological intervention with BH3 mimetic drugs, the promise of MCL1-targeting therapy in AD is also discussed.

Maintaining neuronal integrity and function requires precise mechanisms controlling organelle and protein quality. Alzheimer's disease (AD) is also characterized by functional defects in the clearance and recycling of intracellular components. In fact, neuronal homeostasis involves autophagy, mitophagy, apoptosis, and compromised activity in these cellular processes may cause pathological phenotypes of AD. Therefore, mitophagy is a critical mitochondrial quality-control system, and impaired mitophagy is a hallmark of AD. Myeloid cell leukemia 1 (MCL1), a member of the pro-survival B-cell lymphoma protein 2 (BCL2) family, is a mitochondrially targeted protein that contributes to maintaining mitochondrial integrity. Mcl1-knockout mice display peri-implantation lethality.

Studies on conditional Mcl1-knockout mice have demonstrated that MCL1 plays a central role in neurogenesis and neuronal survival during brain development. Accumulating evidence indicates the critical role of MCL1 as a regulator of neuronal autophagy, mitophagy, and survival.


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Journal reference:

Rezaeian, A-H., et al. (2022) Regulation of neuronal autophagy and cell survival by MCL1 in Alzheimer’s disease. Acta Materia Medica.

Posted in: Medical Science News | Medical Research News | Medical Condition News

Tags: Alzheimer's Disease, Apoptosis, Autophagy, Brain, Cell, Drugs, Intracellular, Knockout, Leukemia, Lymphoma, Mitochondria, Neurogenesis, Organelle, Protein, Research

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